Cathepsin G inhibition by Serpinb1 and Serpinb6 prevent programmed necrosis in neutrophils and monocytes and reduce GSDMD-driven inflammation

Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors. Here, we show that the intracellular protease inhibitors Serpinb1a and Serpinb6a con...

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Publicado en:Cell Rep
Main Authors: Burgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian, Benarafa, Charaf
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350907/
https://ncbi.nlm.nih.gov/pubmed/31216481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.065
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