Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation

BACKGROUND: Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the strategies can result in diverse phenotypes in the resultin...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Biol
Hauptverfasser: Hosur, Vishnu, Low, Benjamin E., Li, Daniel, Stafford, Grace A., Kohar, Vivek, Shultz, Leonard D., Wiles, Michael V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350591/
https://ncbi.nlm.nih.gov/pubmed/32646486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02086-0
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