Bioanalytical Method Development and Validation of Corynantheidine, a Kratom Alkaloid, Using UPLC-MS/MS and its Application to Preclinical Pharmacokinetic Studies

Corynantheidine, a minor alkaloid found in Mitragyna speciosa (Korth.) Havil, has been shown to bind to opioid receptors and act as a functional opioid antagonist, but its unique contribution to the overall properties of kratom remains relatively unexplored. The first validated bioanalytical method...

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Détails bibliographiques
Publié dans:J Pharm Biomed Anal
Auteurs principaux: King, Tamara I., Sharma, Abhisheak, Kamble, Shyam H., León, Francisco, Berthold, Erin C., Popa, Raluca, Cerlati, Orélia, Prentice, Boone M., McMahon, Lance R., McCurdy, Christopher R., Avery, Bonnie A.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350276/
https://ncbi.nlm.nih.gov/pubmed/31838282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.113019
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