Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells

Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely unknown. Here, we characterized fine specificity an...

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Published in:Vaccines (Basel)
Main Authors: Jansons, Juris, Bayurova, Ekaterina, Skrastina, Dace, Kurlanda, Alisa, Fridrihsone, Ilze, Kostyushev, Dmitry, Kostyusheva, Anastasia, Artyuhov, Alexander, Dashinimaev, Erdem, Avdoshina, Darya, Kondrashova, Alla, Valuev-Elliston, Vladimir, Latyshev, Oleg, Eliseeva, Olesja, Petkov, Stefan, Abakumov, Maxim, Hippe, Laura, Kholodnyuk, Irina, Starodubova, Elizaveta, Gorodnicheva, Tatiana, Ivanov, Alexander, Gordeychuk, Ilya, Isaguliants, Maria
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350266/
https://ncbi.nlm.nih.gov/pubmed/32570805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines8020318
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