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Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects

Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential, the number of commercial applications remains scarce. In order to endow them with novel recognit...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Elskens, Jan P., Elskens, Joke M., Madder, Annemieke
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350236/
https://ncbi.nlm.nih.gov/pubmed/32630547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124522
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