Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways

The development of osteoarthritis (OA) is characterized by synovial inflammation and the upregulation of vascular cell adhesion molecule type 1 (VCAM-1) in human osteoarthritis synovial fibroblasts (OASFs). This increase in VCAM-1 expression promotes monocyte adhesion to OASFs. The adipokine resisti...

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Publicat a:Cells
Autors principals: Chen, Wei-Cheng, Lin, Chih-Yang, Kuo, Shu-Jui, Liu, Shan-Chi, Lu, Yung-Chang, Chen, Yen-Ling, Wang, Shih-Wei, Tang, Chih-Hsin
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349127/
https://ncbi.nlm.nih.gov/pubmed/32492888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061369
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