Structure‐based discovery of CZL80, a caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility

BACKGROUND AND PURPOSE: Febrile seizures (FS), the most common seizures in childhood and often accompanied by later epileptogenesis, are not well controlled. Inflammatory processes have been implicated in the pathophysiology of epilepsy. However, whether caspase‐1 is involved in FS generation and co...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Tang, Yangshun, Feng, Bo, Wang, Yi, Sun, Huiyong, You, Yi, Yu, Jie, Chen, Bin, Xu, Cenglin, Ruan, Yeping, Cui, Sunliang, Hu, Gang, Hou, Tingjun, Chen, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348094/
https://ncbi.nlm.nih.gov/pubmed/32346861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15076
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