Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critica...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Feng, Bo, Tang, Yangshun, Chen, Bin, Xu, Cenglin, Wang, Yi, Dai, Yunjian, Wu, Dengchang, Zhu, Junmin, Wang, Shuang, Zhou, Yudong, Shi, Liyun, Hu, Weiwei, Zhang, Xia, Chen, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763292/
https://ncbi.nlm.nih.gov/pubmed/26902320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21931
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