Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung

Smoking-related lung tumors are characterized by profound epigenetic changes including scrambled patterns of DNA methylation, deregulated histone acetylation, altered gene expression levels, distorted microRNA profiles, and a global loss of cytosine hydroxymethylation marks. Here, we employed an enh...

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Udgivet i:Sci Rep
Main Authors: Seiler, Christopher L., Song, J ung Min, Kotandeniya, Delshanee, Chen, Jianji, Kono, Thomas J. Y., Han, Qiyuan, Colwell, Mathia, Auch, Benjamin, Sarver, Aaron L., Upadhyaya, Pramod, Ren, Yanan, Faulk, Christopher, De Flora, Silvio, La Maestra, Sebastiano, Chen, Yue, Kassie, Fekadu, Tretyakova, Natalia Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347915/
https://ncbi.nlm.nih.gov/pubmed/32647312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67502-8
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