Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells

Progression of hepatocellular carcinoma involves multiple genetic and epigenetic alterations that promote cancer invasion and metastasis. Our recent study revealed that hyperphosphorylation of ezrin promotes intrahepatic metastasis in vivo and cell migration in vitro. Celastrol is a natural product...

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Vydáno v:Sci Rep
Hlavní autoři: Du, Shihao, Song, Xiaoyu, Li, Yuan, Cao, Yalei, Chu, Fuhao, Durojaye, Olanrewaju Ayodeji, Su, Zeqi, Shi, Xiaoguang, Wang, Jing, Cheng, Juan, Wang, Tangshun, Gao, Xiang, Chen, Yan, Zeng, Wuzhekai, Wang, Fengsong, Wang, DongMei, Liu, Xing, Ding, Xia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347585/
https://ncbi.nlm.nih.gov/pubmed/32647287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68238-1
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