Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production

Granulomatosis with polyangiitis (GPA) is an autoimmune disease affecting mainly small blood vessels. B-cells are important in the GPA pathogenesis as precursors of autoantibody-producing cells but likely also contribute (auto)antibody-independently. This has been underlined by the effectiveness of...

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Pubblicato in:PLoS One
Autori principali: von Borstel, Anouk, Abdulahad, Wayel H., Dekkema, Gerjan, Rutgers, Abraham, Stegeman, Coen A., Veldman, Johanna, Heeringa, Peter, Sanders, Jan Stephan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347169/
https://ncbi.nlm.nih.gov/pubmed/32645052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235743
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