Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis

Parkinson’s disease is a neurodegenerative disorder characterized by the transmission and accumulation of toxic species of α-synuclein (α-syn). Extracellular vesicles (EVs) are believed to play a vital role in the spread of toxic α-syn species. Recently, peripheral α-syn pathology has been investiga...

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Publicado en:Acta Neuropathol Commun
Autores principales: Sheng, Lifu, Stewart, Tessandra, Yang, Dishun, Thorland, Eric, Soltys, David, Aro, Patrick, Khrisat, Tarek, Xie, Zhiying, Li, Na, Liu, Zongran, Tian, Chen, Bercow, Matthew, Matsumoto, Junichi, Zabetian, Cyrus P., Peskind, Elaine, Quinn, Joseph F., Shi, Min, Zhang, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346449/
https://ncbi.nlm.nih.gov/pubmed/32641150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00983-w
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