Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Parkinson’s disease (PD) pathophysiology develops in part from the formation, transmission, and aggregation of toxic species of the protein α-synuclein (α-syn). Recent evidence suggests that extracellular vesicles (EVs) may play a vital role in the transport of toxic α-syn between brain regions. Mor...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Matsumoto, Junichi, Stewart, Tessandra, Sheng, Lifu, Li, Na, Bullock, Kristin, Song, Ning, Shi, Min, Banks, William A, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598000/
https://ncbi.nlm.nih.gov/pubmed/28903781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0470-4
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