Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer’s disease patients, and it is not clear whether lactate plays...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Long, Dani M., Frame, Ariel K., Reardon, Patrick N., Cumming, Robert C., Hendrix, David A., Kretzschmar, Doris, Giebultowicz, Jadwiga M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346061/
https://ncbi.nlm.nih.gov/pubmed/32484787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103373
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