Epigenome-wide gene–age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients

DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation–age interaction analysis using 1,230 early-stage lung adeno...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chen, Chao, Wei, Yongyue, Wei, Liangmin, Chen, Jiajin, Chen, Xin, Dong, Xuesi, He, Jieyu, Lin, Lijuan, Zhu, Ying, Huang, Hui, You, Dongfang, Lai, Linjing, Shen, Sipeng, Duan, Weiwei, Su, Li, Shafer, Andrea, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Wang, Rui, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Zhang, Ruyang, Chen, Feng, Christiani, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346054/
https://ncbi.nlm.nih.gov/pubmed/32511103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103284
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