Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation. Although the pharmacological DNA demethylation of HSC using 5-aza-2′-d...

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Bibliographische Detailangaben
Veröffentlicht in:Biology (Basel)
Hauptverfasser: Asada, Kiyoshi, Kaji, Kosuke, Sato, Shinya, Seki, Kenichiro, Shimozato, Naotaka, Kawaratani, Hideto, Takaya, Hiroaki, Sawada, Yasuhiko, Nakanishi, Keisuke, Furukawa, Masanori, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Noguchi, Ryuichi, Akahane, Takemi, Yoshiji, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345531/
https://ncbi.nlm.nih.gov/pubmed/32503264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9060117
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