Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation. Although the pharmacological DNA demethylation of HSC using 5-aza-2′-d...

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Publicado en:Biology (Basel)
Main Authors: Asada, Kiyoshi, Kaji, Kosuke, Sato, Shinya, Seki, Kenichiro, Shimozato, Naotaka, Kawaratani, Hideto, Takaya, Hiroaki, Sawada, Yasuhiko, Nakanishi, Keisuke, Furukawa, Masanori, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Noguchi, Ryuichi, Akahane, Takemi, Yoshiji, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345531/
https://ncbi.nlm.nih.gov/pubmed/32503264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9060117
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