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Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes

Congenital heart defects (CHDs) occur with such a frequency that they constitute a significant cause of morbidity and mortality in both children and adults. A significant portion of CHDs can be attributed to aberrant development of the cardiac outflow tract (OFT), and of one of its cellular progenit...

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Detalhes bibliográficos
Publicado no:J Cardiovasc Dev Dis
Main Authors: Vincentz, Joshua W., Clouthier, David E., Firulli, Anthony B.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7344951/
https://ncbi.nlm.nih.gov/pubmed/32325975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcdd7020013
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