Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation

Cancer stem cell (CSC) is a challenge in the therapy of triple-negative breast cancer (TNBC). Intratumoral hypoxia is a common feature of solid tumor. Hypoxia may contribute to the maintenance of CSC, resulting in a poor efficacy of traditional treatment and recurrence of TNBC cases. However, the un...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Yang, Dan, Peng, Meixi, Hou, Yixuan, Qin, Yilu, Wan, Xueying, Zhu, Pengpeng, Liu, Shuiqing, Yang, Liping, Zeng, Huan, Jin, Ting, Qiu, Yuxiang, Li, Qiao, Liu, Manran
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343870/
https://ncbi.nlm.nih.gov/pubmed/32641713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2714-7
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