Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells

MiR-124 is a highly expressed miRNA in the brain and regulates genes involved in neuronal function. We report that miR-124 post-transcriptionally regulates PARP-1. We have identified a highly conserved binding site of miR-124 in the 3′-untranslated region (3′UTR) of Parp-1 mRNA. We demonstrate that...

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Udgivet i:Sci Rep
Main Authors: Dash, Sabyasachi, Balasubramaniam, Muthukumar, Martínez-Rivera, Freddyson J., Godino, Arthur, Peck, Emily G., Patnaik, Srinivas, Suar, Mrutyunjay, Calipari, Erin S., Nestler, Eric J., Villalta, Fernando, Dash, Chandravanu, Pandhare, Jui
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343862/
https://ncbi.nlm.nih.gov/pubmed/32641757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68144-6
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