Extracellular serine controls epidermal stem cell fate and tumor initiation

Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells to transformation remains unknown. Here, we address this question in epi...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Baksh, Sanjeethan C, Todorova, Pavlina K, Gur-Cohen, Shiri, Hurwitz, Brian, Ge, Yejing, Novak, Jesse S S, Tierney, Matthew T, Racelis, June, Fuchs, Elaine, Finley, Lydia W S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343604/
https://ncbi.nlm.nih.gov/pubmed/32451440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0525-9
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