Profiling Ssb-nascent chain interactions reveals principles of Hsp70 assisted folding

The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding. To reveal its working principle, we determined the nascent chain-binding pattern of Ssb at near-residue resolution by in vivo selective ribosome profiling. Ssb associates broadly with cytosolic...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Döring, Kristina, Ahmed, Nabeel, Riemer, Trine, Suresh, Harsha Garadi, Vainshtein, Yevhen, Habich, Markus, Riemer, Jan, Mayer, Matthias P., O'Brien, Edward P., Kramer, Günter, Bukau, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343536/
https://ncbi.nlm.nih.gov/pubmed/28708998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.038
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