The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in C. elegans the overexpression of humanin is sufficient to increase lifespan...

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Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Yen, Kelvin, Mehta, Hemal H., Kim, Su-Jeong, Lue, YanHe, Hoang, James, Guerrero, Noel, Port, Jenna, Bi, Qiuli, Navarrete, Gerardo, Brandhorst, Sebastian, Lewis, Kaitlyn Noel, Wan, Junxiang, Swerdloff, Ronald, Mattison, Julie A., Buffenstein, Rochelle, Breton, Carrie V., Wang, Christina, Longo, Valter, Atzmon, Gil, Wallace, Douglas, Barzilai, Nir, Cohen, Pinchas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343442/
https://ncbi.nlm.nih.gov/pubmed/32575074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103534
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