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Toxicology of tramadol following chronic exposure based on metabolomics of the cerebrum in mice

Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-term use of tramadol can induce several adverse effects. The toxicological mechanism of tramadol abuse is unclear. Metabolomics is a very useful method for investigating the toxicology of drug abuse. We investi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xia, Wei, Liu, Guojie, Shao, Ziyi, Xu, Enyu, Yuan, Huiya, Liu, Junting, Gao, Lina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341866/
https://ncbi.nlm.nih.gov/pubmed/32636435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67974-8
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