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Clinical promise of next-generation complement therapeutics

The complement system plays a key role in pathogen immunosurveillance and tissue homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of inflammatory damage that exacerbates pathology. The clinical merit of targeting the complement system has been established for...

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Dades bibliogràfiques
Publicat a:Nat Rev Drug Discov
Autors principals: Mastellos, Dimitrios C., Ricklin, Daniel, Lambris, John D.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340853/
https://ncbi.nlm.nih.gov/pubmed/31324874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41573-019-0031-6
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