BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology‐directed DNA damage repair to maintain genome stability. Genome‐wide association studies have identi...

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Dades bibliogràfiques
Publicat a:Physiol Rep
Autors principals: Singh, Shweta, Nguyen, Hien, Michels, David, Bazinet, Hannah, Matkar, Pratiek N., Liu, Zongyi, Esene, Lilian, Adam, Mohamed, Bugyei‐Twum, Antoinette, Mebrahtu, Elizabeth, Joseph, Jameela, Ehsan, Mehroz, Chen, Hao H., Qadura, Mohammad, Singh, Krishna K.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340845/
https://ncbi.nlm.nih.gov/pubmed/32638521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14481
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