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BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology‐directed DNA damage repair to maintain genome stability. Genome‐wide association studies have identi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Physiol Rep
Hauptverfasser: Singh, Shweta, Nguyen, Hien, Michels, David, Bazinet, Hannah, Matkar, Pratiek N., Liu, Zongyi, Esene, Lilian, Adam, Mohamed, Bugyei‐Twum, Antoinette, Mebrahtu, Elizabeth, Joseph, Jameela, Ehsan, Mehroz, Chen, Hao H., Qadura, Mohammad, Singh, Krishna K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340845/
https://ncbi.nlm.nih.gov/pubmed/32638521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14481
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