BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology‐directed DNA damage repair to maintain genome stability. Genome‐wide association studies have identi...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Singh, Shweta, Nguyen, Hien, Michels, David, Bazinet, Hannah, Matkar, Pratiek N., Liu, Zongyi, Esene, Lilian, Adam, Mohamed, Bugyei‐Twum, Antoinette, Mebrahtu, Elizabeth, Joseph, Jameela, Ehsan, Mehroz, Chen, Hao H., Qadura, Mohammad, Singh, Krishna K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340845/
https://ncbi.nlm.nih.gov/pubmed/32638521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14481
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