Discovery, Structure-Activity Relationship and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine sidechains and play critical roles in regulating gene transcription. The HAT domain of p300/CBP is a potential drug target for cancer. Through compound screening and medicinal chemistry, novel inhibitors of p300/CBP HA...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Wu, Fangrui, Hua, Yuanda, Kaochar, Salma, Nie, Shenyou, Lin, Yi-Lun, Yao, Yuan, Wu, Jingyu, Wu, Xiaowei, Fu, Xiaoyong, Schiff, Rachel, Davis, Christel M., Robertson, Matthew, Ehli, Erik A., Coarfa, Cristian, Mitsiades, Nicholas, Song, Yongcheng
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340344/
https://ncbi.nlm.nih.gov/pubmed/32314924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b02164
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