Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson’s disease through mitochondrial dysfunction

Parkinson’s disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not clear. We found that expression of COUP-TFII, an orphan nuclear receptor, in DA neurons is upregulated i...

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Udgivet i:PLoS Genet
Main Authors: Kao, Chung-Yang, Xu, Mafei, Wang, Leiming, Lin, Shih-Chieh, Lee, Hui-Ju, Duraine, Lita, Bellen, Hugo J., Goldstein, David S., Tsai, Sophia Y., Tsai, Ming-Jer
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340320/
https://ncbi.nlm.nih.gov/pubmed/32579581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008868
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