Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson’s disease through mitochondrial dysfunction

Parkinson’s disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not clear. We found that expression of COUP-TFII, an orphan nuclear receptor, in DA neurons is upregulated i...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Kao, Chung-Yang, Xu, Mafei, Wang, Leiming, Lin, Shih-Chieh, Lee, Hui-Ju, Duraine, Lita, Bellen, Hugo J., Goldstein, David S., Tsai, Sophia Y., Tsai, Ming-Jer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340320/
https://ncbi.nlm.nih.gov/pubmed/32579581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008868
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi