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Engineering DNA-Functionalized Nanostructures to Bind Nucleic Acid Targets Heteromultivalently with Enhanced Avidity

Improving the affinity of nucleic acids to their complements is an important goal for many fields spanning from genomics to antisense therapy and diagnostics. One potential approach to achieving this goal is to use multivalent binding, which often boosts the affinity between ligands and receptors, a...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Autores principales: Deal, Brendan R., Ma, Rong, Ma, Victor Pui-Yan, Su, Hanquan, Kindt, James T., Salaita, Khalid
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340273/
https://ncbi.nlm.nih.gov/pubmed/32338896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01568
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