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Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein
The multidrug transporter P-glycoprotein (Pgp)/ABCB1/MDR1 plays an important role in multidrug resistance (MDR) and detoxification owing to its ability to efflux an unusually large and chemically diverse set of substrates. Previous phenylalanine-to-alanine scanning mutagenesis of Pgp revealed that n...
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| Publié dans: | IUCrJ |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
International Union of Crystallography
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7340268/ https://ncbi.nlm.nih.gov/pubmed/32695413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252520005709 |
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