Ceftriaxone Relieves Trigeminal Neuropathic Pain Through Suppression of Spatiotemporal Synaptic Plasticity via Restoration of Glutamate Transporter 1 in the Medullary Dorsal Horn

Using a rat model of trigeminal neuropathic pain (TNP) produced by chronic compression of the infraorbital nerve (CCI-ION), we investigated the analgesic effect and the underlying mechanisms of ceftriaxone (Cef), a β-lactam antibiotic, that is thought to be a potent stimulator of glutamate transport...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Luo, Xiao, He, Ting, Wang, Yan, Wang, Jiang-Lin, Yan, Xue-Bin, Zhou, Hao-Cheng, Wang, Rui-Rui, Du, Rui, Wang, Xiao-Liang, Chen, Jun, Huang, Dong
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Cellular Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340123/
https://ncbi.nlm.nih.gov/pubmed/32714151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00199
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