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Identification of activators of human fumarate hydratase by quantitative high-throughput screening

Fumarate hydratase (FH) is a metabolic enzyme that is part of the Krebs-cycle, and reversibly catalyzes the hydration of fumarate to malate. Mutations of the FH gene have been associated with fumarate hydratase deficiency (FHD), hereditary leiomyomatosis, renal cell cancer (HLRCC), and other disease...

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Bibliografiske detaljer
Udgivet i:SLAS Discov
Main Authors: Zhu, Hu, Lee, Olivia W., Shah, Pranav, Jadhav, Ajit, Xu, Xin, Patnaik, Samarjit, Shen, Min, Hall, Matthew D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340117/
https://ncbi.nlm.nih.gov/pubmed/31522598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555219873559
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