Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness

BACKGROUND: High-grade gliomas likely remodel the metabolic machinery to meet the increased demands for amino acids and nucleotides during rapid cell proliferation. Glycine, a non-essential amino acid and intermediate of nucleotide biosynthesis, may increase with proliferation. Non-invasive measurem...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Tiwari, Vivek, Daoud, Elena V, Hatanpaa, Kimmo J, Gao, Ang, Zhang, Song, An, Zhongxu, Ganji, Sandeep K, Raisanen, Jack M, Lewis, Cheryl M, Askari, Pegah, Baxter, Jeannie, Levy, Michael, Dimitrov, Ivan, Thomas, Binu P, Pinho, Marco C, Madden, Christopher J, Pan, Edward, Patel, Toral R, DeBerardinis, Ralph J, Sherry, A Dean, Mickey, Bruce E, Malloy, Craig R, Maher, Elizabeth A, Choi, Changho
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Neuroimaging
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339885/
https://ncbi.nlm.nih.gov/pubmed/32055850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa034
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