Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness

BACKGROUND: High-grade gliomas likely remodel the metabolic machinery to meet the increased demands for amino acids and nucleotides during rapid cell proliferation. Glycine, a non-essential amino acid and intermediate of nucleotide biosynthesis, may increase with proliferation. Non-invasive measurem...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Tiwari, Vivek, Daoud, Elena V, Hatanpaa, Kimmo J, Gao, Ang, Zhang, Song, An, Zhongxu, Ganji, Sandeep K, Raisanen, Jack M, Lewis, Cheryl M, Askari, Pegah, Baxter, Jeannie, Levy, Michael, Dimitrov, Ivan, Thomas, Binu P, Pinho, Marco C, Madden, Christopher J, Pan, Edward, Patel, Toral R, DeBerardinis, Ralph J, Sherry, A Dean, Mickey, Bruce E, Malloy, Craig R, Maher, Elizabeth A, Choi, Changho
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Neuroimaging
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339885/
https://ncbi.nlm.nih.gov/pubmed/32055850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa034
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