Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improves ocular penetration of loperamide

Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance (MDR) efflux proteins, beside tight junction proteins, in the blood ocular barriers (BOB). Hence, the purpose of the current research was to investigate the abili...

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Publicado en:J Pharm Sci
Autores principales: Janga, Karthik Yadav, Tatke, Akshaya, Shukla, Surabhi, Lamichhane, Surya P, Avula, Bharathi, Wang, XiangDi, Jablonski, Monica M., Khan, Ikhlas A., Majumdar, Soumyajit
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339865/
https://ncbi.nlm.nih.gov/pubmed/29678592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.04.008
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