Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improves ocular penetration of loperamide

Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance (MDR) efflux proteins, beside tight junction proteins, in the blood ocular barriers (BOB). Hence, the purpose of the current research was to investigate the abili...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Janga, Karthik Yadav, Tatke, Akshaya, Shukla, Surabhi, Lamichhane, Surya P, Avula, Bharathi, Wang, XiangDi, Jablonski, Monica M., Khan, Ikhlas A., Majumdar, Soumyajit
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339865/
https://ncbi.nlm.nih.gov/pubmed/29678592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.04.008
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