Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improves ocular penetration of loperamide

Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance (MDR) efflux proteins, beside tight junction proteins, in the blood ocular barriers (BOB). Hence, the purpose of the current research was to investigate the abili...

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Dettagli Bibliografici
Pubblicato in:J Pharm Sci
Autori principali: Janga, Karthik Yadav, Tatke, Akshaya, Shukla, Surabhi, Lamichhane, Surya P, Avula, Bharathi, Wang, XiangDi, Jablonski, Monica M., Khan, Ikhlas A., Majumdar, Soumyajit
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339865/
https://ncbi.nlm.nih.gov/pubmed/29678592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.04.008
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