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P-glycoprotein restricts ocular penetration of loperamide across the blood ocular barriers: a comparative study in Mdr1a knock-out and wild type Sprague Dawley rats.
The current research was undertaken to determine the existence and magnitude of P-glycoprotein (P-gp) expression on the blood ocular barriers by studying the ocular penetration of loperamide, a specific P-gp substrate, in P-gp (Mdr1a) knock-out (KO) and wild type (WT) Sprague Dawley rats. A clear, s...
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| Publicado no: | AAPS PharmSciTech |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7325844/ https://ncbi.nlm.nih.gov/pubmed/29520587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-018-0979-2 |
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