NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner

BACKGROUND: Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence. Nicastrin (NCSTN), a core subunit of γ-Secretase, has been reported to play a vital role in...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Li, Hui, Lan, Tian, Xu, Lin, Liu, Hailing, Wang, Jinju, Li, Jiaxin, Chen, Xiangzheng, Huang, Jiwei, Li, Xuefeng, Yuan, Kefei, Zeng, Yong, Wu, Hong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339515/
https://ncbi.nlm.nih.gov/pubmed/32631394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01638-3
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