CRISPR-sub: Analysis of DNA substitution mutations caused by CRISPR-Cas9 in human cells

CRISPR-Cas9 induces DNA cleavages at desired target sites in a guide RNA-dependent manner; DNA editing occurs through the resulting activity of DNA repair processes including non-homologous end joining (NHEJ), which is dominant in mammalian cells. NHEJ repair frequently causes small insertions and d...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Hwang, Gue-Ho, Yu, Jihyeon, Yang, Soyeon, Son, Woo Jae, Lim, Kayeong, Kim, Heon Seok, Kim, Jin-Soo, Bae, Sangsu
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338987/
https://ncbi.nlm.nih.gov/pubmed/32670508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.06.026
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