Effects of Thermally Induced Configuration Changes on rAAV Genome’s Enzymatic Accessibility

Physical titers for recombinant adeno-associated viral (rAAV) vectors are measured by quantifying viral genomes. It is generally perceived that AAV virions disassemble and release DNA upon thermal treatment. Here, we present data on enzymatic accessibility of rAAV genomes when AAV virions were subje...

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Bibliografski detalji
Izdano u:Mol Ther Methods Clin Dev
Glavni autori: Xu, Yinxia, Guo, Ping, Zhang, Junping, Chrzanowski, Matthew, Chew, Helen, Firrman, Jenni A., Sang, Nianli, Diao, Yong, Xiao, Weidong
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338580/
https://ncbi.nlm.nih.gov/pubmed/32671135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.06.005
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