Effects of Thermally Induced Configuration Changes on rAAV Genome’s Enzymatic Accessibility

Physical titers for recombinant adeno-associated viral (rAAV) vectors are measured by quantifying viral genomes. It is generally perceived that AAV virions disassemble and release DNA upon thermal treatment. Here, we present data on enzymatic accessibility of rAAV genomes when AAV virions were subje...

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Publicat a:Mol Ther Methods Clin Dev
Autors principals: Xu, Yinxia, Guo, Ping, Zhang, Junping, Chrzanowski, Matthew, Chew, Helen, Firrman, Jenni A., Sang, Nianli, Diao, Yong, Xiao, Weidong
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338580/
https://ncbi.nlm.nih.gov/pubmed/32671135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.06.005
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