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Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development

Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we previously demonstrated perlecan deficiency leads to reduced cellular and ECM stiffness in vivo. This change in mechanics may lead to the e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cell Proteomics
Päätekijät: Ocken, Alexander R., Ku, Madeline M., Kinzer-Ursem, Tamara L., Calve, Sarah
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Biochemistry and Molecular Biology 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338092/
https://ncbi.nlm.nih.gov/pubmed/32381549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.001998
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