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Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development
Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we previously demonstrated perlecan deficiency leads to reduced cellular and ECM stiffness in vivo. This change in mechanics may lead to the e...
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| Udgivet i: | Mol Cell Proteomics |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Biochemistry and Molecular Biology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7338092/ https://ncbi.nlm.nih.gov/pubmed/32381549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.001998 |
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