Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development

Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we previously demonstrated perlecan deficiency leads to reduced cellular and ECM stiffness in vivo. This change in mechanics may lead to the e...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Ocken, Alexander R., Ku, Madeline M., Kinzer-Ursem, Tamara L., Calve, Sarah
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338092/
https://ncbi.nlm.nih.gov/pubmed/32381549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.001998
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