Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue

The stress-induced c-Jun N-terminal kinase (JNK) controls microtubule dynamics by enhancing both microtubule growth and rescues. Here, we show that upon cell stress, JNK directly phosphorylates the microtubule rescue factor CLIP-170 in its microtubule-binding domain to increase its rescue-promoting...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Henrie, Hélène, Bakhos-Douaihy, Dalal, Cantaloube, Isabelle, Pilon, Antoine, Talantikite, Maya, Stoppin-Mellet, Virginie, Baillet, Anita, Poüs, Christian, Benoit, Béatrice
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337496/
https://ncbi.nlm.nih.gov/pubmed/32491151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201909093
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