Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue

The stress-induced c-Jun N-terminal kinase (JNK) controls microtubule dynamics by enhancing both microtubule growth and rescues. Here, we show that upon cell stress, JNK directly phosphorylates the microtubule rescue factor CLIP-170 in its microtubule-binding domain to increase its rescue-promoting...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Henrie, Hélène, Bakhos-Douaihy, Dalal, Cantaloube, Isabelle, Pilon, Antoine, Talantikite, Maya, Stoppin-Mellet, Virginie, Baillet, Anita, Poüs, Christian, Benoit, Béatrice
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337496/
https://ncbi.nlm.nih.gov/pubmed/32491151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201909093
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