KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study

Mutations in KRAS, NRAS, and BRAF (RAS/BRAF) genes are the main predictive biomarkers for the response to anti-EGFR monoclonal antibodies (MAbs) targeted therapy in metastatic colorectal cancer (mCRC). This retrospective study aimed to report the mutational status prevalence of these genes, explore...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sanchez-Ibarra, Hector Eduardo, Jiang, Xianli, Gallegos-Gonzalez, Elena Yareli, Cavazos-González, Adriana Carolina, Chen, Yenho, Morcos, Faruck, Barrera-Saldaña, Hugo Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337295/
https://ncbi.nlm.nih.gov/pubmed/32628708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235490
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