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Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2
Human TPH2 (hTPH2) catalyzes the rate-limiting step in CNS serotonin biosynthesis. We characterized a single-nucleotide polymorphism (C2755A) in the hTPH2 gene that substitutes tyrosine for serine at position 41 in the regulatory domain of the enzyme. This polymorphism is associated with bipolar dis...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7336366/ https://ncbi.nlm.nih.gov/pubmed/24899127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12779 |
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