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The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease

INTRODUCTION: Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. METHODS: We investigated whether the presence of a common TH polymorphism...

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Publicado en:Parkinsonism Relat Disord
Main Authors: Tekin, Izel, Carkaci-Salli, Nurgul, Lewis, Mechelle M., Mailman, Richard B., Huang, Xuemei, Vrana, Kent E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770791/
https://ncbi.nlm.nih.gov/pubmed/26732803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2015.12.015
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