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The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease
INTRODUCTION: Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. METHODS: We investigated whether the presence of a common TH polymorphism...
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| Publicado no: | Parkinsonism Relat Disord |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4770791/ https://ncbi.nlm.nih.gov/pubmed/26732803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2015.12.015 |
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