Reduced Ebola vaccine responses in CMV(+) young adults is associated with expansion of CD57(+)KLRG1(+) T cells

CMV is associated with immunosenescence and reduced vaccine responses in the elderly (>70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18–50 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adeno...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Bowyer, Georgina, Sharpe, Hannah, Venkatraman, Navin, Ndiaye, Pierre Birahim, Wade, Djibril, Brenner, Nicole, Mentzer, Alex, Mair, Catherine, Waterboer, Tim, Lambe, Teresa, Dieye, Tandakha, Mboup, Souleymane, Hill, Adrian V.S., Ewer, Katie J.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336307/
https://ncbi.nlm.nih.gov/pubmed/32413101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200004
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