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Calmodulin/Calcineurin Interaction Beyond the Calmodulin-binding Region Contributes to Calcineurin Activation
Calcineurin (CaN) is a calcium-dependent phosphatase involved in numerous signaling pathways. Its activation is in part driven by the binding of calmodulin (CaM) to a CaM-recognition region (CaMBR) within CaN’s regulatory domain (RD). However, secondary interactions between CaM and the CaN RD may be...
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| 發表在: | Biochemistry |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7336278/ https://ncbi.nlm.nih.gov/pubmed/31483613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00626 |
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