Physical confinement induces malignant transformation in mammary epithelial cells

The physical microenvironment of tumor cells plays an important role in cancer initiation and progression. Here, we present evidence that confinement – a new physical parameter that is apart from matrix stiffness-can also induce malignant transformation in mammary epithelial cells. We discovered tha...

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Udgivet i:Biomaterials
Main Authors: Lu, Yen-Chun, Chu, Tinyi, Hall, Matthew S., Fu, Dah-Jiun, Shi, Quanming, Chiu, Alan, An, Duo, Wang, Long-Hai, Pardo, Yehudah, Southard, Teresa, Danko, Charles G., Liphardt, Jan, Nikitin, Alexander Yu, Wu, Mingming, Fischbach, Claudia, Coonrod, Scott, Ma, Minglin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336132/
https://ncbi.nlm.nih.gov/pubmed/31271857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119307
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